Pre-2000

Main content

1999

Chorismate Mutase from Bacillus subtilis is partially diffusion controlled.
Mattei, P.; Kast, P.; Hilvert, D. Eur. J. Biochem., 1999, 261, 25-32.

Chemoenzymatic synthesis of isotopically labeled chorismic acids.
Gustin, D. J.; Hilvert, D.; J. Org. Chem., 1999, 64, 4935-4938.

Catalysis by antibodies.
Hilvert, D. in Comprehensive Natural Products Chemistry 1999. Volume 5: Enzymes, Enzyme Mechanisms, Proteins and Aspects of NO Chemistry; Elsevier: Oxford, UK; 1999.

Heavy atom isotope effects reveal a highly polarized transition state for chorismate mutase.
Gustin, D. J.; Mattei, P.; Kast, P.; Wiest, O.; Lee, L.; Cleland, W. W.; Hilvert, D. J. Am. Chem. Soc., 1999, 121, 1756-1757.

a-Functionalized phosphonyl-phosphinates: Synthesis and evaluation as transcarbamoylase inhibitors.
Flohr, A.; Aemissegger, A.; Hilvert, D. J. Med. Chem., 1999, 42, 2633-2640.

Electric fields in active sites: Substrate switching from null to strong fields in thiol- and selenosubtilisins.
Dinakarpandian, D.; Shenoy, B. C.; Hilvert, D.; McRee, D. E.; McTigue, M.; Carey, P. R. Biochemistry, 1999, 38, 6659-6667.

Stereoselective reactions with catalytic antibodies.
Hilvert, D. Topics in Stereochem., 1999, 22, 83-135.

An antibody-catalyzed allylic sulfoxide-sulfenate rearrangement.
Zhou, Z. S.; Flohr, A.; Hilvert, D. J. Org. Chem., 1999, 64, 8334-8341.

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.
Xu, J.; Deng, Q.; Chen, J.; Houk, K. N.; Bartek, J.; Hilvert, D.; Wilson, I. A. Science, 1999, 286, 2345-2348.


1997/98 

Redesigning enzyme topology by directed evolution.
G. MacBeath, P. Kast & D. Hilvert,  Science 1998, 279, 1958

Probing enzyme quaternary structure by combinatorial mutagenesis and selection
MacBeath G, Kast P, Hilvert D, Protein Science, 1998, 7(8), 1757-1767.

Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity.
G. MacBeath, P. Kast & D. Hilvert, Protein Science 1998, 7, 325-335.

Selenosubtilisin's peroxidase activity does not require an intact oxyanion hole.
E.B. Peterson & D. Hilvert,  Tetrahedron 1997, 53, 12311-12317.

An antibody-catalyzed selenoxide elimination.
Z.S. Zhou, N. Jiang & D. Hilvert,  J. Am. Chem. Soc. 1997, 119, 3623-3624.


Up to 1997 (selected publications) 

Selection of a functional linker for a catalytic single-chain antibody using phage display technology.
Y. Tang, N. Jiang, C. Parakh & D. Hilvert, J. Biol. Chem. 1996, 271, 15682-15686.

Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection:  The importance of electrostatic catalysis.
P. Kast, M. Asif-Ullah, N. Jiang & D. Hilvert,  Proc. Natl. Acad. Sci. USA 1996, 93, 5043-5048.

Nonessential active site residues modulate selenosubtilisin's kinetic mechanism.
E.B. Peterson & D. Hilvert,  Biochemistry 1995, 34, 6616-6620.

Large rate accelerations in antibody catalysis by strategic use of haptenic charge.
S.N. Thorn, R.G. Daniels, M.-T.M. Auditor & D. Hilvert,  Nature 1995, 373, 228-230.

Chemical synthesis of proteins.
D. Hilvert,  Chemistry & Biology 1994, 1, 201-203.

Routes to catalysis:  The structure of a catalytic antibody and comparison with its natural counterpart.
M.R. Haynes, E.A. Stura, D. Hilvert & I.A. Wilson,  Science 1994, 263, 646-652.

 
 
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